Retrosynthesis – Online Organic Chemistry Tutor

Retrosynthesis - Online Organic Chemistry Tutor

It is an analytical technique in which the decomposition or fragmentation of a targeted organic molecule is used to produce the starting material, commonly referred to as a “synthon”.

fragments produced through a particular pattern of breakage. It is called retrosynthesis because it is a reversible process of chemical synthesis. EJ Corey gives this concept in his book Logic of chemical synthesis.

It includes some terminology such as:

Disconnection means breaking of bonds between atoms.

Reagents are the ingredients used in chemical synthesis.

The synthon ion or radical is formed after a dissociation.

FGI or FGE was written as double arrow, functional group interconnection or equivalence.

Rules of retro synthesis:

  • All the received fragment ions should be in their stable forms.
  • The number of fragmented ions after the dissociation of a bond should be as low as possible.
  • The breaking of the bond always occurs through a carbon hetero atom and due to the higher electronegativity than carbon they accommodate their lone pair.
  • It is not always possible to obtain permanent ions after dissociation; In that case, FGI (Functional Group Interconnection) can be used to obtain a sufficiently stable ion.
  • Fragmented ions can be positively or negatively charged and are therefore replaced by the required chemical fragments.
  • The relationship between existing groups needs to be known. If a proper directing group is present it must be truncated at the end to obtain the target molecule.
  • First, the electron-withdrawing group must be truncated.
  • In some cases FGI is required then it should be done in proper stage for desired orientation.
  • Orders that require more steps or additional reactions should be avoided.
  • If a compound consists of two parts then the heteroatom must be next to the heteroatom to be removed.

the gain:

  • To get a clear idea about the structure of naturally available compounds.
  • It is a useful technique for preparing a compound to analyze the mechanism of reaction and biological metabolism. A good example is labeled compound.
  • Preparation of medicinal compounds, dyes, polymers etc. useful to mankind.
  • Novel problems required modern solutions that would lead to the development of modern chemistry.

Leave a Reply

Your email address will not be published.

Related Post