Fluorescent and Bioluminescent Probes for Imaging and Diagnostics (Prof. Kai Johnson) – NCCR in Chemical Biology

Fluorescent and Bioluminescent Probes for Imaging and Diagnostics (Prof. Kai Johnson) - NCCR in Chemical Biology

In November 2022, Professor Kai Johnson, Director of the Department of Chemical Biology at the Max Planck Institute (MPI) for Medical Research, and Professor at the Institute of Chemical Sciences and Engineering of the cole Polytechnique Fédérale de Lausanne (EPFL), will give A talk about “Fluorescent and Bioluminescent Probes for Imaging and Diagnostics” at the International Symposium on Chemical Biology. During this hybrid event taking place in and virtually in Geneva, he will present insights on how a combination of protein engineering and synthetic chemistry can be used to generate fluorescent and bioluminescent probes for live-cell imaging.

considered One of the most creative and innovative experts in chemical biology, Kai Johnson’s current research interests focus on the development and application of chemical approaches to visualize and manipulate biochemical activities in living cells. His past achievements include: Development of several new protein-labeling techniques (snap-tag and clip-tag) for bioimagingAll of which have proven to be commercially successful and have become indispensable for biomedical imaging worldwide.

Through targeted modification of proteins, Kai Johnson’s group has also been successful in creating new protein-based biosensors for use in diagnostics., He has also helped to elucidate the mechanism of action of many drugs, and has been involved in the development of new drugs for chronic pain.

Kai Johnson encourages and supports start-ups based on the knowledge and technology of his group. Some of these have become full-fledged businesses such as Covalys Biosciences, acquired by New England Biolabs, which commercializes SNAP and CLIP technologies, or Spirochrome SA, a company co-founded by Kai Johnson, which provides the scientific community with fluorescent probes. Bioimaging.

,Kai was my co-director and in a way a co-founder of NCCR Chemical Biology. He is also a pioneer in chemical biology, inventing self-labeling protein technology and turn-on fluorescent probes for cell-labeling.Professor Howard Reisman, former director of NCCR Chemical Biology and member of the NCCR Steering Committee, says.

Professor Kai Johnson will review his talk at the 2022 International Symposium on Chemical Biology Attempts to introduce new fluorescent dye and sensor proteins that allow to visualize biochemical activities in living cells with high spatial and temporal resolution, He will also discuss how these sensors can be used for point-of-care drug monitoring.

EMBO Keynote Speaker at the 2022 Symposium in Geneva

is kai johnson Director of the Max Planck Institute for Medical Research, Department of Chemical Biology since 2017. He was appointed as full professor at EPFL’s Institute of Chemical Science and Engineering and as co-director of NCCR Chemical Biology. Currently, he focuses on the development and application of chemical approaches to study and manipulate protein function. In the past, they pioneered ways to specifically label proteins in living cells; Of these, snap-tags and clip-tags have become popular tools in the chemical biology community.

Kai Johnson obtained his PhD in chemistry after working with Steven Benner from ETH Zurich (1992) in Switzerland. He did a post-doc with Peter Schultz from UC Berkeley, (1993–1996). He joined the faculty of EPFL in 1999 and became Director in MPI for Medical Research in 2017. In 2002, Kai Johnson published a book with Susan Brackman. Directed molecular evolution of proteins: or how to improve enzymes for biocatalysis, they . was associate editor of ACS Chemical Biology Executive Editor from 2005 to 2010 and from 2021 Journal of the American Chemical Society, He is a member of the editorial advisory board of science and was a member of the Research Council of the Swiss National Science Foundation from 2011-17. He has received the Prix APLE for Invention of the Year 2013 of the EPFL, Novartis Lectureship Award 2012/13, Karl-Heinz Bekurts Prize 2016 and is an elected member of EMBO.

To go further

Leave a Reply

Your email address will not be published.

Related Post